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KMID : 0358219920190010081
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Korean Journal of Fertility and Sterility
1992 Volume.19 No. 1 p.81 ~ p.86
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Pulsatile GnRH Therapy in Male Patients with Hypogonadotropic Hyprogonadism
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박기현
지용석/이병석/이보연/노동제/송찬호/이무상/최형기/이현철
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Abstract
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The effects of pulsatile GnRH therapy have been studied for the treatment of different forms of hypogonadotropic hypogonadism, including idiopathic hypogonadotropic hypogonadism and hypogonadism developed as a result of treatment with combination
of
surgery and irradiation for pituitary or hypothalamic tumor. GnRH was administered subcutaneously in a dose of 10μg every 2 hours with the pulsatile infusion pump. With GnRH therapy, all patients improved secretion of LH, FSH and testosterone.
Testicular volumes increased. Spermatogenesis was induced in 8 patients. Pulsatile GnRH therapy is an effective treatment for idicpathic hypogonadotropic hypogonadism and can have a role in hypogonadism previously treated with combination of
surgery and
irradiation for pituitary or hypothalamic tumor.
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KEYWORD
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